Pulsed electromagnetic ﬁeld (PEMF) is emerging as innovative treatment for regulation of inﬂammation, which could have signiﬁcant effects on tissue regeneration. PEMF modulates inﬂammatory processes through the regulation of pro- and anti-inﬂammatory cytokine secretion during different stages of inﬂammatory response. Consistent outcomes in studies involving animal and human tissue have shown promise for the use of PEMF as an alternative or complementary treatment to pharmaceutical therapies. Thus, PEMF treatment could provide a novel nonpharmaceutical means of modulating inﬂammation in injured tissues resulting in enhanced functional recovery.
This review examines the effect of PEMF on immunomodulatory cells (e.g., mesenchymal stem/ stromal cells [MSCs] and macrophages [MF]) to better understand the potential for PEMF therapy to modulate inflammatory signaling pathways and improve tissue regeneration. This review cites published data that support the use of PEMF to improve tissue regeneration. Our studies included herein confirm anti-inflammatory effects of PEMF on MSCs and MF.
Keywords: pulsed electromagnetic field (PEMF), inflammation, regeneration, mesenchymal stem cells (MSCs), macrophages (THP-1s), muscle cells (C2C12).